Insulin Resistance and Alzheimer's Progression
Research presented at the Congress 2025 reveals that insulin resistance, detected by the triglyceride-glucose (TyG) index, can predict rapid cognitive decline in Alzheimer's patients.
A study involving 315 non-diabetic patients found those with mild cognitive impairment due to Alzheimer's and high TyG levels deteriorated four times faster than those with lower levels.
Implications for Early Intervention and Treatment
The findings suggest insulin resistance could be a modifiable target for early lifestyle or pharmacological interventions, potentially delaying Alzheimer's progression.
Researchers are now exploring whether TyG levels correlate with neuroimaging biomarkers, aiming for earlier detection and stratification of Alzheimer's patients.